Towering fast bowler Mohammad Irfan is set to make his debut after being included in the squad for the first match. In the second change to their Twenty20 side that lost the second match on Tuesday, Pakistan have dropped opener Shahzaib Hasan and included middle-order batsman Asad Shafiq.
Shafiq and Irfan were called up to the Pakistan squad as reinforcements for the three players accused of spot-fixing, Mohamma Amir, Mohammad Asif and Salman Butt.
England have dropped wicketkeeper Craig Kieswetter for Steve Davies, while Jonathan Trott replaces dropped batsman Kevin Pietersen. Batting all-rounder Ravi Bopara is also in the side, replacing Luke Wright.
Meanwhile, the match has been reduced to a 41-overs-a-side match after heavy rain delayed the start in Durham.
Covers were still in place on the pitch at the scheduled 1015BST (0915GMT) start of what was supposed to be a 50-over match following overnight and morning rain.
Pakistan: Mohammad Hafeez, Kamran Akmal, Asad Shafiq, Mohamma Yousuf, Umar Akmal, Fawad Alam, Shahid Afridi, Umar Gul, Saeed Ajmal, Shoaib Akhtar, Mohammad Irfan
England: Andrew Strauss (captain), Steve Davies, Jonathan Trott, Paul Collingwood, Eoin Morgan, Ravi Bopara, Tim Bresnan, Michael Yardy, Graeme Swann, Stuart Broad, James Anderson.
Umpires: Billy Doctrove and Iain Gould
Third umpire: RA Kettleborough
Match referee: Jeff Crowe
Reserve umpire: RK Illingworth